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New Biology Search
Sample queries
Protein/gene related queries (with examples)
Protein-protein Interactions
DIABLO binding proteins
Downstream targets of a protein
Proteins upregulated by Cathepsin C
Proteins downregulated by Cathepsin C
Protein modification targets
AKT1 phosphorylation targets
PP2A dephosphorylation targets
DNMT1 methylation targets
KDM1A demethylation targets
Tip60 acetylation targets
SIRT1 deacetylation targets
Protein regulators
Cathepsin C protein activators
Cathepsin C protein inhibitors
p53 regulatory transcription factors
p53 promoter binding
Protein modification
phosphorylation of p53
dephosphorylation of p53
acetylation of p53
deacetylation of p53
methylation of p53
demethylation of p53
Protein expression regulators
Cathepsin C expression activators
Cathepsin C expression inhibitors
Small molecule regulators of proteins
asparaginase small molecule activators
asparaginase small molecule inhibitors
Proteins and Diseases
diseases associated with Cathepsin C
Proteins and Cell Processes
cell processes regulated by Cathepsin C
Antibodies to Proteins
antibodies against p53
Drug/compound related queries (with examples)
Drug/compound protein targets
proteins activated by 7-Ketocholesterol
proteins inhibited by 7-Ketocholesterol
Proteins directly regulated by drug/compounds
proteins directly activated by glucose
proteins directly inhibited by glucose
Drug/compound relation types
7-Ketocholesterol and proteins
7-Ketocholesterol and diseases
7-Ketocholesterol and cell processes
Disease related queries (with examples)
Disease Biomarkers
malaria biomarkers
malaria prognostic biomarkers
malaria diagnostic biomarkers
Disease-related Genetic Changes
proteins mutated in cardiomegaly
genes deleted in asthma
genes epigenetically changed in asthma
Disease-related Quantitative/State Changes
genes alternatively spliced in asthma
protein activity changes in asthma
proteins abnormally phosphorylated in asthma
metabolite changed in asthma
Disease-related small molecule effectors
preeclampsia small molecule inducers
preeclampsia small molecule inhibitors
Disease relation types
cerebral palsy and proteins
cerebral palsy and small molecules
cerebral palsy and diseases
cerebral palsy and cell processes
Cell process related queries (with examples)
Cell process regulators
fatty acid synthesis inducers
fatty acid synthesis inhibitors
Cell process relation types
fatty acid synthesis and proteins
fatty acid synthesis and small molecules
fatty acid synthesis and diseases
Discoveries built on extracted relations
Finding the right information in the literature can be tedious. Common search engines retrieve publications based on the mere presence of your search terms somewhere in the text. It is up to you to review the hitlist for the actual information needed. But what if a search engine recognized the context of your search based on the biologically relevant connection between your search terms? And then retrieved a list of facts that match that connection, plus the source document and sentence. Introducing New Biology Search or NBS.

How does it work?

MedScan® NLP is a proprietary natural language processing technology we use at Elsevier to automatically extract biologically relevant facts from published literature. Using syntactic and semantic analyses, the system identifies and extracts essential facts based on predefined properties and interrelationships of entities in the biomedical literature. So the sentence “We have shown that ETS1 can stimulate GM-CSF in Jurkat T cells” becomes the standardized database structure Activate(ETS1, GM-CSF), and a search for “proteins activated by ETS1” retrieves this and other records containing evidence of a protein being activated by ETS1.

MedScan NLP currently extracts high-quality contextual facts from 28.6M Medline® abstracts and 10,000 journal titles, and has generated a repository of 10.6M unique relations (biological facts) supported by 56.6M references.

What we would like you to do

Watch the video here that shows you how NBS works, and then perform as many searches as you can think of, using our sample queries as a guide. As you explore the tool, consider whether the system is interpreting your search terms as you expect, browse through results and explore the resulting data tables and graphs. In the end, please fill out the short questionnaire here.

Getting Started

Click to expand the list of sample queries under the NBS search box above. Select any search of interest to transfer it to the search box and click Search. Feel free to also substitute terms in the query.

On the resulting page, results are tabulated for an easy overview of the relations found. Each row highlights a hit, the type of relation between the two entities, and the direction of that relation. If known, mechanism underlying the relation is also listed. Click any entity or relation to reveal more detailed information.
Click Open Graph View to reveal a graphical representation of the results. You can also switch between different views using "View" button in the upper right corner.
 

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